He is bisexual and sees himself as an 'equal opportunity lover', including with the protagonist, Yukari 'Caroline' Hayasaka as shown in episodes like 'Atlier' and 'Future,' and Isabella previously had a relationship with Joji. Isabella was assigned male at birth, but lives as a trans woman as revealed in the episode 'Rose.' Robin Brenner calls the character 'one of the most realistic and accepting portrayals of a transgender character in anime,' with the same applying to the manga. She acts as a mother figure to the members of ParaKiss and inspired George to make several dresses for Isabella since childhood. She harbors romantic feelings for Shizuru, as shown from the first episode of the series, with Tomoe having a dark side as revealed later in the series.
Rojo was confirmed to be a lesbian by co-creator Duncan Rouleau on Apand she was in a relationship with fellow gang member Azul.
